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Polynucleotides – Skin

Polynucleotides are injectable treatments derived from purified DNA fragments, typically sourced from salmon or trout. These molecules are designed to rejuvenate and regenerate the skin by stimulating collagen production, improving elasticity, and enhancing hydration.

About our Polynucleotides

At DaVinci Medical Aesthetics, polynucleotides are injectable treatments derived from purified DNA fragments, typically sourced from salmon or trout. These molecules are designed to rejuvenate and regenerate the skin by stimulating collagen production, improving elasticity, and enhancing hydration. Once injected, polynucleotides stimulate fibroblast activity, promoting tissue repair and collagen production. They also act as antioxidants, scavenging free radicals to protect the skin from damage. This process improves skin texture, elasticity, and hydration while reducing fine lines and wrinkles. Polynucleotides can be used on various areas, including the face, neck, décolletage (chest), hands, and even delicate regions like under the eyes and lips. They are effective for treating scars, stretch marks, and skin laxity.

How it Works

Undergoing a thorough consultation with a qualified medical professional prior to receiving polynucleotide treatment is critical for ensuring both safety and optimal results. During this assessment, the clinician evaluates your anatomy, medical history, and specific aesthetic goals to determine if you are a suitable candidate and to craft a tailored treatment plan. It also provides a dedicated space to discuss potential risks, set realistic expectations, address any concerns, and receive clear pre- and post-treatment guidelines, minimising complications and helping achieve natural-looking outcomes.

Formalising a treatment plan specifically for polynucleotides is essential for ensuring patient safety, precise anatomical targeting, and predictable aesthetic results. This structured plan details the exact injection sites, precise dosage units per epidermal area/ group, treatment intervals, and long-term maintenance strategy tailored to the individual’s unique facial dynamics. By establishing a clear baseline and recording subtle dosage adjustments over time, it provides a transparent record that supports informed consent, monitors facial symmetry and movement, and ensures consistent, natural-looking outcomes across every session.

Safety and ethics in mind always, our medical professionals will delivery your polynucleotide plan to the highest degree of accuracy and suitability. 

With each treatment of polynucleotides you receive at any of our clinics, we ensure the best outcome is achieved by ongoing reviews and check-ins by your practitioner.

Should we need to adjust anything in the plan, this allows us to be reactive and ensure we are heading to your goals.

 

Note – polynucleotides results are not instant! They are excellent for long term skin and hair health improvement.

Candidates for
Polynucleotide treatment

  • Are at least 18 years of age
  • Are in good physical and mental health
  • Have good skin elasticity
  • Have realistic expectations
  • Want to improve skin health without surgery
  • Don’t exhibit medical contraindications

Polynucleotides are ideal for patients seeking to restore their facial appearance without surgeries. If you want to reverse the signs of aging and maintain youthful, smooth, healthy skin, please contact our medical injectors. We will carefully review your medical history, discuss your goals, and determine if you are suitable for polynucleotide injections.

Our Medical Team

Board-Certified Team

Success Stories

100% 5-star rating across Google and Social Media

5/5

Such a lovely experience from start to finish. I had a Blue Peel and was made to feel completely comfortable throughout the treatment. Everything was explained clearly and professionally, and I felt like I was in very knowledgeable hands. I especially appreciated that there was absolutely no pressure to buy products or treatments I didn’t need — the advice felt genuinely tailored to me and my skin rather than sales-focused. Very professional, knowledgeable and welcoming. I would definitely recommend!

Medical Peel
5/5

The consultation was extremely professional and helpful, the Davinci medical aesthetics clinic took great care to find exactly the right treatment for my skin concerns. I have already completed 2 sessions of microneedling, and I can see a clear improvement in my skin - both its overall texture , and my pigmentation/blemishes have smoothed and faded significantly . I'm very happy with the results so far!

Microneedling
5/5

I had a very good experience. Naila was extremely kind, polite and knowledgeable. She explained every procedure clearly and answered all of my questions with patience which made me feel comfortable throughout my visit. I am very satisfied with the care I received and would highly recommend this clinic to anyone looking for quality aesthetic treatments.

Skin Care
5/5

Absolutely loved my treatment! Naila is professional, friendly and really attentive. I’m so pleased with the results and would definitely recommend her. I’ll be back! ❤️

Skin Care
5/5

Today I came to DaVinci Medical, wow what a stunning clinic, fresh & clean throughout. I had a lovely treatment off Naila, I had a skin peel (chemical peel) Naila is lovely, was super welcoming and extremely knowledgeable, I am so glad I came to DaVinci for my treatment, my skin feels amazing and I have the gorgeous glow I was looking for, I can’t wait to come back for my second session, thankyou again!

Medical Peel
5/5

Great treatment lovely and true advice will be going back with out a doubt lovely people.

Skin Care
have a question?

Quick answers to questions you may have

During a polynucleotide procedures, a qualified medical professional uses a very fine needle to administer small, precise amounts of medicament into specific dermal areas. The treatment is quick (typically taking 15 to 30 minutes) with minimal downtime. Prior to injection, your skin is thoroughly cleansed, and injection site mapping is performed to ensure accurate placement. You may feel a mild pinprick sensation, but the procedure is generally well-tolerated without the need for local anaesthetic.

No. When administered by an experienced medical injector, polynucleotide targets only the specific dermal areas responsible for healthy looking skin while preserving your natural facial movement and expressions. The objective is to achieve a refreshed, genuinely healthy appearance rather than a “frozen” look, allowing you to smile, frown, and express yourself naturally all while glowing with health.

No. Polynucleotides do not affect sensory nerves or act as a local anaesthetic. You will retain your complete sense of touch, temperature, and feeling in all treated areas.

Polynucleotide treatments are non-permanent, and require loading phases with gaps of 2 to 4 weeks for your recommended course. With results typically lasting between 6 to 12 months with maintenance. Spacing sessions 2–4 weeks apart allows the initial cellular stimulation to stack, compounding the production of new collagen, elastin, and extracellular matrix before the previous signal fades. Your practitioner will advise on the ideal time-frame as part of your bespoke treatment plan.